For all of the Mizzou grads out there missing all the fun we
had in PBL . . . here is a case for you!
PBL CASE
Page One:
28 year old female presents to clinic with lower abdominal
pain. She states that she is 6 months
pregnant. She denies any nausea,
vomiting, diarrhea. She denies any
urinary symptoms. Denies any fever. ROS is otherwise negative.
PE: Vitals: BP 132/85, HR 78 HEENT:
No pallor
Chest:
CTAB, RRR Abdomen: Gravid,
Non-tender
Extremities:
No pedal edema
What further questions do you want to ask?
What is your differential diagnosis?
Page Two:
The patient states that she has been attending the
anti-natal care clinic. When reviewing
the records from ANC, you see that the midwives have never been able to hear a
fetal heart rate. On further questioning
the patient states that she has not felt the baby moving. She denies any recent bleeding, discharge, or
loss of fluid.
What is your differential diagnosis?
Should any further diagnostic testing be performed?
Page Three:
An ultrasound of the uterus is performed and the image obtained is below:
What is your diagnosis?
What further testing and treatment needs to be done?
Page Four:
Ultrasound of the liver was normal. CXR was normal.
A suction dilatation and curettage (suction D&C) was performed. The tissue below was expelled from the
uterus.
What is your diagnosis?
What further management and treatment does this patient need?
OBJECTIVE: Molar Pregnancy
Otherwise known as gestational trophoblastic disease, a
molar pregnancy is an abnormal form of pregnancy where a non-viable fertilized
egg implants into the uterus and grows into a mass. A molar pregnancy can develop when an egg
that is missing its nucleus is fertilized.
They are categorized into partial or complete moles depending on the
number of chromosomes present. A
complete mole is caused by a single sperm that combines with an egg that has
lost its DNA. The sperm then replicated
its DNA to make a “complete” 46 chromosome set: typically 46,XX but occasionally
46, XY can be seen. In contrast a
partial mole happens when an egg with DNA is fertilized by two sperm or by one
sperm that replicates its DNA. The
genotypes usually seen are 69, XXY or 92, XXXY.
Hydatidiform
moles are seen occurring once in every 1000 pregnancies in the US. Rates in Asia are much higher and in
Indonesia are up to 1 in every 100 pregnancies.
Potential risk factors may include defects in the egg, uterus
abnormalities, or nutritional deficiencies (diets low in protein, folic acid,
and carotene). Women under 20 and over
40 years of age have a higher risk of developing a molar pregnancy.
Molar
pregnancies usually present with bleeding in the 4th-5th
month of pregnancy. The patient usually
experiences more vomiting then would be expected with pregnancy and
hypertension. The uterus is found to
larger than expected for the given month of the pregnancy. Blood tests will show very high levels of hCG. Diagnosis can be made by ultrasound. The mole resembles a “cluster of grapes” or
“snow-storm” on ultrasound. However,
definitive diagnosis requires histopathologic examination where one will see
increased trophoblast proliferation and enlarging of the chorionic villi.
The
treatment for a molar pregnancy is to evacuate the uterus by suction or by
curettage as soon as the diagnosis is made.
After removal of the mole the level of hCG in the patient’s blood is
followed until it reaches undetectable levels.
80% of moles are benign, however 2-3% of cases, the mole may develop
into choriocarcinoma (complete moles have a higher risk than do partial moles). This is a very rapidly-growing, malignant,
and metastatic form of cancer; however despite these poor features the rate of
cure after treatment with chemotherapy, most commonly methotrexate, is
high. Over 90% of women with
non-metastatic disease survive and retain their ability to conceive and bear
future children. In women with
metastatic disease, 75-85% are cured, but usually their ability to have future
children is lost.
I am learning a lot here in Ghana. I missed this diagnosis the first time I saw
it. I had to show the ultrasound to the
long term MD here because I had no idea what I was looking at. Since that time I have seen a few more cases while
here in Ghana. This case was actually
brought to me by one of the PA students to review because he was having a hard
time “locating the uterus.” How things
have come full circle in just a few months!